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December 28, 2020
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December 29, 2020Table of Contents
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Cialis is a golden solution for ED (erectile dysfunction) whatever the cause or the severity of ED as it a safe, well-tolerated, and efficacious treatment.
Cialis has been studied in a lot of clinical trials which approved its efficacy not only in the general ED populations but also in people with severe ED and other comorbidities.
Cialis has a long duration of action and long therapeutic window even with once daily dosing and on-demand dosing, effective blood concentrations has been achieved.
Its once-daily dosing disconnects the temporal association of dosing a medication prior to the sexual encounter. This makes Cialis a distinct, efficacious, and favorable treatment of ED.
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Cialis versus Viagra
There are a lot of trials compare between Cialis and viagra, these studies declared that most of the patients and their partners preferred Cialis over viagra for the treatment of ED.
In a study conducted to determine the number of patients on Viagra who prefer to switch to Cialis versus those who resume on it, the portion of the patients who switched to Cialis was 90.5% (133 of 147) irrespective of their age or severity or etiology of ED.
Another prospective study conducted over 750 men founded that most of them prefer Cialis by significant margins.
A 66.5 % of men preferred Cialis over Viagra in a crossover study of 215 men for initiation of ED therapy.
A study that focused on the effect of comorbidities on the preference of patients stated that 87% of men with diabetes had a preference for Cialis over Viagra and men with hypertension had a 79% preference for Cialis.
The largest and most recent study of viagra and Cialis included 291 men who did not take any of them before, randomized for taking one drug for 12 weeks followed by the other for another 12 weeks. the patient did not know the drug they took first, after the 24 weeks, 71% men chose Cialis compared to 29% viagra.
The Partner’s Preference Study was a randomized, crossover study comparing Cialis and viagra in 100 couples with the male partner having erectile dysfunction, and the primary outcome was that the female partners were preferred Cialis by 79.2%, while 15.6% preferred sildenafil.
The female partners reported more relaxed, more satisfying, and longer-lasting sexual experiences with Cialis as compared with viagra.
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Cialis Safety and drug interactions
Cialis is absolutely contraindicated with any medication that contains nitrate as this combination can cause severe hypotension and as Cialis has a long duration of action any nitrate medications must be stopped 48 hours after ingestion of Cialis, compared with 24 hours with viagra.
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Cialis was first discovered as a treatment for angina pectoris secondary to their action of smooth muscle relaxation. All of Cialis trials have monitored study participants’ vital signs, particularly heart rate and blood pressure, monitored drug effects on the heart, and the numbers of cardiovascular adverse events.
A review of more than 4000 patients from over 60 studies stated that Cialis does cause small changes in blood pressure, but that the changes were not clinically significant.
Cialis does not cause increased hypotension or orthostatic hypotension with concomitant use with other antihypertensive drugs except with a group of drugs called alpha blockers used to treat hypertension and benign prostatic hyperplasia (BPH) in men.
This interaction with alpha blockers is as a result of similar mechanism of action which leads to additive effect of hypotension.
Alpha blockers are drugs like doxazosine, tamsulosin and alfuzosin.
In a study to evaluate effect of using cialis Coupled with doxazosin (Cardura®) and tamsulosin (Flomax®), it was found that the hypotensive effect of cardura was exaggerated when combined with Cialis, and The authors concluded tamsulosin to be a safe α-blocker to administer concurrently with Cialis.
Precaution is recommended with the use of Cialis with any alpha blockers including other alpha blockers like labetalol, carvedilol until more studies are conducted. buy Cialis online Canadian pharmacy
Recently, the FDA recommended precautionary Co administration rather than contraindicated co-administration.
Cialis is susceptible to changes in blood concentration by other drugs that inhibit or promote its breakdown.
Drugs that can increase level of cialis include ketoconazole, erythromycin, grapefruit juice. A dose reduction may be considered.
On the contrary, drugs including rifampin, carbamazepine, phenytoin, and phenobarbital, would require a larger dose of Cialis for a similar clinical effect.
