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Adverse reactions
Incidence >10%:
- Cardiovascular: Flushing (10% to 19%)
- Central nervous system: Headache (16% to 46%)
- Gastrointestinal: Dyspepsia (3% to 17%; dose-related)
- Ophthalmic: vision color changes, Visual disturbance (2% to 11%; including blurred vision, and photophobia; dose-related)
- Respiratory: Epistaxis (9% to 13%)
Incidence 2% to 10%:
- Central nervous system: Insomnia (≤7%), dizziness (2% to 4%), paresthesia (≤3%)
- Dermatologic: Erythema (6%), skin rash (1% to 3%)
- Gastrointestinal: Diarrhea (3% to 9%), gastritis (≤3%), nausea (2% to 3%)
- Respiratory: Nasal congestion (4% to 9%), exacerbation of dyspnea (≤7%), nasal congestion (4%), rhinitis (4%), sinusitis (3%)
- Genitourinary: Urinary tract infection (3%)
- Hepatic: Increased liver enzymes (2% to 10%)
- Neuromuscular & skeletal: Myalgia (2% to 7%), back pain (3% to 4%)
- Miscellaneous: Fever (6%)
Incidence <2%
Buy sildenafil citrate online uk Postmarking, and/or case reports (limited to important or life-threatening): Abdominal pain, abnormal hepatic function tests, amnesia , anemia, eye hemorrhage, anxiety, asthma, auditory impairment, bone pain, bronchitis, burning sensation of eyes, cardiac failure, cataract, cerebral hemorrhage, cerebral thrombosis, cerebrovascular hemorrhage, chest pain, chills, colitis, contact dermatitis, depression, dermal ulcer, drowsiness, dry eye syndrome, dysphagia, edema, ejaculatory disorder, eye pain, eye redness, facial edema, falling, gout, hearing loss, hematuria, hemorrhage, hyperglycemia, hypernatremia, hypersensitivity reaction, hypertension, hypertonia, hyperuricemia, hypoesthesia, hypoglycemia, hypotension, increased bronchial secretions, increased cough, increased intraocular pressure, increased thirst, ischemic heart disease, leukopenia, migraine, neuropathy, nocturia, orthostatic hypotension, ostealgia, osteoarthritis, otalgia, pain, palpitations, peripheral edema, photophobia, prolonged erection, pruritus, pulmonary hemorrhage, rectal hemorrhage, rupture of tendon, seizure, skin photosensitivity, stomatitis, subarachnoid hemorrhage, swelling of eye, syncope, temporary vision loss, tinnitus, tremor, unstable diabetes, urinary frequency, urinary incontinence, urticaria, vertigo, visual field loss, vomiting, weakness.
overdose
Overdose results from exceeding the maximum daily dose of 100 mg and even with a dosing frequency more than once per day.
Sildenafil has no relevant genotoxicity or carcinogenic properties, reproductive toxicity, low general toxicity, and a substantial safety margin.
Clinical studies of doses higher than the maximum showed an increased frequency and severity of adverse drug reactions, including a dose-related increase in the frequency of visual adverse events.
With administration more than once a day, there was an increase in the muscular ache, which was transient and without evidence of muscular damage, and dyspepsia.
In the postmarking safety database, cases were related to suicides or suicide attempts, the reporting rate for overdose was 2.3% (884/39,203).
Overdose adverse events in the postmarking were generally known about sildenafil (i.e. Headache and flushing).
Priapism was reported at a rate more than twice that of the overall postmarking safety database. Of the 884 patients with overdose identified in the postmarking safety database, 165 reported a first total daily dose > 100 mg.
In this subset, the reporting rate was more than twice that for the overall postmarking safety database for myocardial infarction (6.1% vs. 2.5%), acute myocardial infarction (3.0% vs. 0.7%), malaise (2.4% vs. 1.0%), drug interaction (4.8% vs. 2.4%), dyspnea (2.4% vs. 1.0%), tachycardia (2.4% vs. 1.0%) and hypotension (5.5% vs. 1.1%).
Although a relationship with sildenafil overdose cannot be excluded in 4 of the 12 patients had a myocardial infarction and in 14 of the 57 died, also no relationship between overdose and increased cardiac risk can be assumed based on the small number of postmarking cases.
However, we recommend admission to hospital and cardiac monitoring for forty eight hours to be addressed by experienced healthcare professionals. supportive care is required, but renal dialysis will not accelerate clearance because sildenafil is mainly cleared by liver not in urine.
Overdose with sildenafil is not common in the ED population. In doses up to 240 mg/day, the safety profile was unchanged compared with lower dosages.
In studies of doses up to 800 mg, adverse reactions were similar to those with lower doses, but the rate and severity were increased.
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