Diazepam UK

Diazepam UK:

Diazepam UK is one of the medication groups belong to the benzodiazepine group. Also, it may be classified as an anticonvulsant drug.

What are diazepam UK indications?

Diazepam UK has a lot of indications. Some of them are FDA approved and others are off-label used.

1. FDA-approved indications: that means the effect of the drug is revised and found that benefit out weight the risk.

Examples of FDA approved indications of diazepam:

 

• Alcohol withdrawal symptoms.
• Sedation before surgery.
• Treatment of muscle spasms, spasticity.

2. Off-label indications: which is not FDA-approved for this indication, while approved for another indication, another age group, or other doses.

Examples of off label indications of diazepam:

• Neuroleptic malignant syndrome: for management of muscle rigidity or anxiety in patients with severe symptoms at presentation (hyperthermia, muscle ache)
• Opioid withdrawal.
• Vertigo, acute episodes.
• Intoxication (cocaine, methamphetamine).
• Sleep disorders (insomnia).

Diazepam UK adverse effects:

• Agitation,
• Muscle weakness.
• Blurred vision.
• Abdominal pain.
• Respiratory depression.

Diazepam UK contraindications:

If you have one of the following medical conditions you should avoid diazepam use:

• Hypersensitivity or allergic reaction.
• Severe hepatic impairment.
• Pregnancy or planning.
• Respiratory depression.
• Sleep apnea: sudden stop breathing during sleep, one of the sleep disorders.
• Acute narrow-angle glaucoma.
• Myasthenia gravis: skeletal muscle weakness due to autoimmune disease.
• Pediatric population (age under 6months of age).

Diazepam UK warnings and precautions:

There are many precautions you should know before starting diazepam if you suffer from one of the following conditions:

• Respiratory depression: especially when using opioids with diazepam.
• Allergic reaction: some people showed the experience of allergic reactions like swelling tongue, lips, and face. If you have an allergy to diazepine your doctor will advise you to avoid diazepam.
• Sedation: especially when concomitant use with another benzodiazepine or opioid over sedation and other side effect risks increased, avoid concomitant use it is a solution.
• Hepatic impairment: severe hepatic impairment is contraindicated to use diazepam otherwise use it under the supervision of your doctor.
• Renal impairment: use of diazepam with caution if you have renal impairment.
• Glaucoma: acute narrow-angle glaucoma is considered a contraindication for using diazepam.
• Abuse, misuse that is lead to physical dependence.

Diazepam UK drug interactions:

You need to revise your medications with your doctor before start taking diazepam as their many medications increase or decrease the effectiveness of Diazepam.

• Drugs should be avoided concomitant use with diazepam:
• Fusidic acid (systemic).
• Metronidazole (systemic).
• Drugs decrease the effect of diazepam:
• Theophylline derivatives.
• Drugs increase effects of diazepam:
• Fusidic acid.
• Kava Kava.

Diazepam UK food interactions:

You should take care if you take diazepam when you eat or drink certain food like:

• Alcohol: drinking alcohol increase the sedation effect of diazepam, you may feel more drowsy, tired, or dizzy. Avoid concomitant with diazepam.
• Grapefruit: concomitant use with diazepam increase its level in the blood, so increases its side effects.

Don’t do the following during taking diazepam:

• Don’t drive.
• Don’t operate machinery.
• Don’t take diazepam without check with your doctor.
• Don’t take diazepam with alcohol, grapefruit, or medications that interact with it.
• Don’t take diazepam for a long duration, that is increased risk of abuse, and physical dependence.
• Don’t use diazepam if your age over 65 years.
• Don’t stop diazepam suddenly if you suffer from seizures.
• Don’t recommend or give diazepam to anyone who feels pain seems to yours.
• Don’t start diazepam without referring it to your doctor.

Diazepam UK overdose, symptoms, and treatment:

Use of other medications increase level of diazepam or drinking alcohol which increases the risk of overdose and serious adverse effects.

Symptoms of diazepam overdose:

• Respiratory depression.
• Muscle weakness.
• Low blood pressure.
• Blurred vision.
• Upset stomach.
• Lips and nails turning blue.

Treatment of diazepam overdose:

• Activated charcoal.
• Maintain a clear airway.
• Closely monitor overdose symptoms.
• Management of hypotension.
• Monitor the level of consciousness.
• Take diazepam antidote: flumazenil is an antidote used in diazepam toxicity.

Your doctor will advise you to monitor certain vital signs if show any abnormalities stop medication:

• Heart rate.
• Respiratory rate.
• Blood pressure.
• Level of consciousness.

And other labs value like:

• Complete blood count.
• Liver enzyme.

 

Special population and diazepam:

• Elderly: diazepam should use with caution in the elderly due to its decrease in its clearance from the body, so you should start with a low dose and increase gradually.
• Pregnancy: contraindications in pregnancy as increased risk of adverse effects on the fetus.
• Breastfeeding: secreted in milk so contraindication in breastfeeding.
• Pediatric: should not use under 6 months of age.
• Psychotic: should not use in psychotic patients.

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