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Eszopiclone 3mg helps you sleep for a longer time, decreases sleep onset latency, and gives you persistence in sleeping without frequent disturbances, so you can wake up the next day freshly with no hangover or residuals effects.

 

The clinical trials performed in eszopiclone to assess efficacy were for 6 months. The final formal assessments approved its use in induce sleeping and maintaining it. 

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Dosage 

 

Dose in adults starts with 1mg once daily nightly and can increase according to response to 3mg. 

(remember don’t increase dose by yourself, consult your doctor if eszopiclone not working).

 

Dosing in special population

 

Elderly:

start with 1mg before bedtime and because there are many reports that the drug increase risk of fall and diminished functions of the central nervous system with the elderly, the maximum dose can be increase to 2mg if indicated and with whom complain of problems in maintaining the sleep.

 

Hepatic disease:

use with caution, never increase dose than 2mg in severe hepatic disease.

 

Renal disease:

no dose adjustment is recommended as clinical trials found no alteration in the level of drugs with patients who have renal disease.

Use with drugs which alerted elimination of eszopiclone:

dose may need to be changed.

 

Warnings and precautions for eszopiclone use

 

There are no contraindications for eszopiclone use except hypersensitivity to any of its components (as hypersensitivity could reach to an extent which called anaphylaxis, a life-threatening condition appears initially as breathing difficulties, wheezing, clammy skin, and fast heartbeats which could lead to death.

 

Caution must be paid to patients who suffer from depression or any suicidal tendencies as the risk of eszopiclone overdose and abuse increases with those people.

 

In the clinical trials of eszopiclone only one case has been reported with a dose of 36mg but the user got recovered.

 

A dose of 7mg of eszopiclone does not induce any respiratory depression in healthy volunteers but if you have any respiratory disease tell your doctor.

 

Tolerance is a common problem with hypnotic drugs but clinical trials revealed that 6 months of use of eszopiclone doesn’t induce any tolerance and the drug was still effective.

 

The risk of dependence and abuse increases with a hypnotic agent so if you have any problem with drug or alcohol abuse tell your doctor. Eszopiclone is a federally controlled substance (C-IV). Keep it in a safe place and don’t share with others and do not resell it anyway as it is against the law.

 

Persistent insomnia is an indication that there is a problem so if you used eszopiclone for 7 to 10 days with no effect this may indicate the presence of primary psychiatric illness. 

 

Adverse drug reactions:

 

The premarketing development program for eszopiclone revealed a group of adverse effects. 

 

The most common (incidence >2) were: unpleasant taste, headache, somnolence, respiratory infection, dizziness, dry mouth, rash, anxiety, hallucinations, and viral infections. If you notice any of them tell your doctor immediately.

 

You may experience events like sleep-walking, sleep-driving, and engaging in other activities while you not fully awake, tell your doctor immediately if this happens.

 

The premarketing evaluation states that the majority of these adverse reactions were dose-related and severity increased with high doses.

 

The post-marketing survey is characterized by increase dysosmia reporting (olfactory dysfunction which means loss of sense of smell).

 

Drug interaction

 

Drugs that can cause additive central nervous system shutdown like other hypnotics and alcohol this increase residuals effects next day and impaired normal functions like think freshly and be able to concentrate or drive, a dose reduction should be considered.

 

The use of eszopiclone 3mg with other hypnotics at bedtime or the middle of the night is not recommended.

 

Drugs contain paroxetine: use paroxetine 20mg and eszopiclone 3mg for 7 days cause differentiation of both drugs characters.

 

Drugs contain olanzapine: use olanzapine at dose 10mg with eszopiclone 3mg alerted the level of both drugs in the blood.

 

Pregnancy and lactation

 

Oral administration of eszopiclone in pregnant rats and rabbits showed no teratogenicity effects even with highest doses but there are no well-controlled trials in humans so use eszopiclone only if he potentials benefits outweigh the expected risks.

 

It is not known if eszopiclone can be reach to breast milk, so use with caution. 

 

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