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Zopiclone is a hypnotic drug used to induce sleep and decrease sleep-onset latency. The Use of zopiclone should be with caution and under the supervision of a physician.
We will discuss in the following topic the safety issues related to zopiclone use.
Disease-related concerns:
- buy zopiclone Depression: Zopiclone should be Used with caution in patients with depression. Worsening of depression including suicide attempts and suicidal ideation is associated with the use of hypnotics. Intentional overdose may be an issue in this population; the least amount of drug should be used.
- Drug abuse: patients with a history of alcoholism, drug abuse, or significant personality disorders have the potential for drug dependency and tolerance especially with prolonged use. This risk increases with higher dosage and longer duration of therapy.
- Hepatic impairment: patients with mild-to-moderate hepatic impairment should be used zopiclone cautionary; dosage adjustment recommended. Avoid use in severe hepatic insufficiency.
- Renal impairment: zopiclone clearance mainly depends on the liver so the accumulation of zopiclone or its metabolites is not an issue with renal impairment; the manufacturer labeling however recommends a dose reduction and to use with caution.
- Respiratory disease: patients with chronic respiratory disease should not use zopiclone.
Concurrent drug therapy issues:
- Opioids: buy zopiclone has a Canadian Boxed Warning about its Concomitant use with opioids as this can result in profound sedation, respiratory depression which can lead to coma, and death. concomitant prescribing should be only reserved in cases of no alternatives with Limitations to dosages and durations and following for signs and symptoms of respiratory depression and sedation.
Special populations:
- Debilitated patients: zopiclone should be used with caution in those patients and dose reduction may be required.
- Elderly: Elderly patients are more susceptible to adverse reactions (eg, anorexia, anxiety, agitation, confusion, falls, anterograde amnesia).
- Fall risk: zopiclone increase the risk of fall.
Other warnings/precautions:
- Appropriate use: good evaluation about causes of insomnia should be initiated before starting symptomatic treatment with zopiclone and use should generally not exceed 7 to 10 days.
Failure of therapy after 7 to 10 days may indicate primary illness completely, and in this case re-evaluation of the patient should occur when treatment is required for more than 2 to 3 consecutive weeks.
- Rapid onset: administer zopiclone immediately before bedtime or after you go to bed and is having difficulty falling asleep because of zopiclone rapid onset.
- Withdrawal: increased awakenings during sleep and a longer sleep-onset latency may occur for 1 to 2 days after the discontinuation of zopiclone.
Abrupt discontinuation or large decreases in dose may result in a more severe withdrawal syndrome especially after sustained use and is characterized by confusion, delirium, anxiety, disorientation, euphoria, hypertension, abdominal pain, insomnia, irritability, restlessness, speech difficulties, seizures, and tremor.
This withdrawal syndrome is generally mild and not common and can resolve within weeks or after reinitiating of zopiclone.
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