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We spend about one-third of our lives asleep. The amount of the sleep changes by age and varies according to every human nature.

 

Sleep difficulties are common, with up to 35% of the population affected. Of interest, 4%–5% of The population may experience hypersomnia.

 

Insomnia is defined as an inability to initiate or maintain sleep and can be associated with problems during the daytime. About one-third of the population experiences insomnia, with one-half of them saying it is serious.

 

More than 40% of those with insomnia self-medicate with over-the-counter medications or other substances (e.g., alcohol).

 

There are different types of insomnia:

 

Transient insomnia (less than 1 week), is most often associated with acute stressors. Transient insomnia resolves once the acute stressors has resolved. Drugs can be used on an irregular basis until the acute event resolved.

 

Short-term insomnia (less than 4 weeks), is also most often associated with an acute stressor, but it is ongoing. Drugs can be holded after two to three nights of good sleep. Therapy for 7–10 days is usually sufficient.

 

chronic insomnia may indicate the presence of a medical or psychiatric cause, If a cause is not present, a common type of chronic insomnia is chronic psychophysiological insomnia, which is a behavioral problem. 

 

The Z-drugs are the new group of agent used to treat insomnia rather than the traditional benzodiazepine, this group includes Zolpidem (Ambien), zopiclone (Imovane), eszopiclone (Lunesta), and zaleplon (sonata). 

 

Zopiclone has the longest duration of action of the Z-drugs, so zopiclone can help you initiate and maintain sleep.

 

The clinical trials of Zopiclone were conducted for a period up to 17 weeks stated that Imovane 7.5mg improved sleep parameters with chronic insomnia and no tolerance have developed. 

 

How many I should take from Imovane 7.5mg? 

 

If you between 18 to 65 years start with a dose of 7.5 mg. 

 

If you younger than 18 years do not use it. 

 

If you are older than 65 years reduced dose is advised (3.75 mg) and can be then increased to the maximum dose (7.5 mg). This dose is optimal to help you fall to sleep if taken orally 30 to 60 min before going to bed.

 

If you have renal or hepatic diseases start with a dose of 3.75 mg

 

Imovane side effects and overdose

 

Imovane 7.5mg has very good feedback from users as most of the adverse reactions were well tolerated. In the large postmarketing surveillance, included patients aged 15 to 80 years, The most common reported adverse events in this study were:

 

• The difficulty arising in the morning (1.3%).
• bitter taste (3.6%)
• dry mouth (1.6%)

A deterioration of psychomotor functions and memory loss have been reported with Imovane use 1 to 2 hours after administration, but only minimum residual effects remained after 8 to 10 hours. 

 

The users of Imovane 7.5 must be warned about the potential risk of engaging in complex behaviors while asleep when taking sedative-hypnotics. Such behaviors may include driving, eating, having sex, or talking on the telephone while asleep (with amnesia for the event).

 

Administration of Imovane and alcohol (ethanol 0.2 to 0.8 gm per kg) has an additive suppressant effect on psychomotor functions after 1.5 hours from intake, and resolved completely after 8 hours. 

 

Consider use Imovane 12 hours before any activity requires concentrating like driving or using heavy machines.

 

Imovane has a minimum effect on respiratory functions.

 

Imovane contains lactose so if you have any sugar intolerance avoid using it.

 

No physical dependence observed in studies conducted on psychiatric patients or alcoholics at a dose of 30mg/day, however there are some case reports of dependence that have developed in a patient with a history of substance abuse. 

 

Rare case reports have been published about Imovane overdose, volunteer patients have been exposed to overdose and only severe suppression for functions of the central nervous system had noticed.

 

Imovane and Pregnancy 

 

The Motherisk Program, the Toronto Teratogen Information Service has been studied the effect of zopiclone on 40 mothers during pregnancy and compared them with normal mothers have no teratogenic risk factors, the result was that there is no increase in malformations accompanied with zopiclone intake.

 

Some other studies approved that taking Imovane near baby delivery time increased the chance of withdrawal symptoms in the baby. 

 

Imovane and lactation

 

A small amount of Imovane passes to the milk so changing breastfeeding time according to the dose time is recommended, talk to your doctor or midwife about this.