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Valium for sale online in the UK

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Table of Contents

  • Valium for sale online 
    •  Some of these indications and doses:
      • Procedural anxiety (premedication):
      • Alcohol withdrawal syndrome:
      • Discontinuation of therapy:
      • Dosing in renal Impairment:
        • Dosing in hepatic Impairment
        • Dosing in geriatric
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  • Diazepam (Valium) is one of the most successful drugs from the onset of the psychopharmacological revolution which began in the 1950s. It is very effective in treating a wide spectrum of central nervous system disorders, including anxiety and epilepsy, it set the standard for pharmacotherapy in terms of the onset of action, potency, and safety.

 

 Some of these indications and doses:

  • anxiety:

In acute and severe cases as a monotherapy or with other agents

 2 to 10 mg every 3 to 6 hours as needed up to 40 mg/day; the choice of dose based on response and tolerability.

Anxiety disorders as a monotherapy or with other agents (alternative agent):

Note valium used for symptoms relief as a short-term therapy until concurrent therapy is effective for example use for less than 12 weeks. Long-term therapy may be considered only for select patients when other treatments are ineffective or poorly tolerated. 

The initial dose is 2 to 5 mg once or twice daily; increase gradually according to the response and tolerability up to 40 mg/day in 2 to 4 divided doses.

Procedural anxiety (premedication):

Dose ranges from 2 to 10 mg once 30 to 60 minutes before the procedure; if dosa needed again due to incomplete response, may repeat the dose (50% of the initial dose) after 30 to 60 minutes.

 

  • Muscle spasm, spasticity, and/or rigidity (alternative agent):

The initial dose is 2 mg twice daily or 5 mg at bedtime; may be increased gradually according to the response and tolerability, up to 40 to 60 mg/day in 3 to 4 divided doses.

  • Substance withdrawal:

Alcohol withdrawal syndrome:

Symptom-triggered regimen: 5 to 20 mg as needed until appropriate sedation achieved; dose and frequency determined by withdrawal symptom severity.

Fixed-dose regimen: 10 mg every 6 hours for 1 day, then 5 mg every 6 hours for 2 days; additional doses may be considered based on withdrawal symptoms.

Note: Symptom-triggered regimens preferred over fixed-dose regimens. 

  • Vertigo, acute episodes, treatment as an alternative agent (off-label use):

 1 mg to 5 mg every 12 hours for 24 to 48 hours.

Discontinuation of therapy:

In patients receiving extended or higher-dose valium therapy, unless safety concerns require a more rapid withdrawal, gradually withdraw to detect reemerging symptoms and minimize rebound and withdrawal symptoms. 

The total daily dose should be tapered by 10% to 20% every 1 to 2 weeks according to the response and tolerability. The optimal taper rate is not constant and duration will vary, tapering may take up to 6 months for easier withdrawal and tolerability. 

For example, reduce the dose every week by 25% until half of the dose remains. Thereafter, continue to reduce 12% every 4 to 7 days.

Dosing in renal Impairment:

No dosage adjustments are provided for valium use.

Valium isn’t dialyzable only 0% to 5% so no supplemental dose is necessary.

 

Dosing in hepatic Impairment

The oral tablets are contraindicated in severe hepatic impairment, use with caution because clearance of valium may decrease significantly. 

 

Dosing in geriatric

Start with a low Initial dose if age is more than 65 years: 2 to 2.5 mg 1 to 2 times daily; increase gradually according to response and tolerability.

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