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Diazepam 10 mg UK
Diazepam 10 mg UK is a derivative of the benzodiazepines family, it has anxiolytic, hypnotic, and anticonvulsant properties.
Diazepam works by potentiating the inhibitory effects of GABA (gamma-aminobutyric acid), a certain transmitter in the brain.
It is a controlled substance that should not be used except under the supervision of a doctor, and should not be shared with others.
Uses and indications:
Diazepam 10 mg UK is used in,
- Anxiety conditions associated with tension, excitation, agitation, fear, or aggressiveness such as anxiety due to stress conditions, and anxiety states with physical expressions
- Acute alcohol withdrawal
- Symptomatic treatment of acute agitation, tremors, and delirium
- Adjunctive therapy in relaxation of muscles spasms caused by inflammation of muscles and joints or secondary to trauma
- Spasticity (a condition caused by abnormally increased muscle tone or stiffness of muscles), this condition is caused by upper motor neuron disorders like cerebral palsy (a group of disorders affecting the balance and posture) and paraplegia (a type of paralysis)
- Premedication for the nervous patient undergoing dental procedures
- Premedication before having surgery
- Adjunctive therapy in certain types of epilepsy
It is also prescribed for children in,
- Control of tension and irritability in selected cases of cerebral spasticity
- Adjunctive therapy for muscles spasms in tetanus
- Oral premedication in certain cases
The nasal spray form of diazepam is indicated in patients 6 years old and older patients in the treatment of seizure activity different from the usual pattern of seizure in these patients.
Dosage and administration:
In adults, diazepam 10 mg UK is used by the following doses,
The treatment of anxiety states:
2 – 10 mg every 6 – 12 hours
No more than 30 mg every 8 hours
In the treatment of alcohol withdrawal symptoms:
10 mg every 6 – 8 hours during the first 24 hours, then the dose is reduced to 5 mg every 6 – 8 hours
As adjunctive therapy in the management of muscles spasms:
2 – 10 mg every 6 – 12 hours
In patients with renal impairment: The dose doesn’t need to be adjusted except if it is going to be used for a long time.
In patients with hepatic impairment: The maintenance dose is decreased by 50%
Diazepam 10 mg UK may seriously interact if used with different substances.
Diazepam 10 mg UK seriously interacts with the following drugs and alternatives should be used.
- calcium/magnesium/potassium/sodium oxybates
- erythromycin base
- erythromycin ethylsuccinate
- erythromycin lactobionate
- erythromycin stearate
- metoclopramide intranasal
- sodium oxybate
- St John’s Wort
- sufentanil SL
Diazepam 10 mg UK interacts with grapefruit and grapefruit juice leading to serious side effects.
Don’t change the amounts of grapefruit taken in your diet before talking with your doctor.
Diazepam 10 mg UK taking with alcohol increases the sedative effects of alcohol, including drowsiness, dizziness, and tiredness.
Obesity increases the distribution of the drug in fats which may lead to increased risks of toxicity.
Diazepam 10 mg UK should be used carefully in obese patients to avoid toxicity.
That’s why, the loading doses are determined based on actual body weight, while maintenance doses are determined on ideal body weight to avoid toxicity.
If you suffer from the following diseases, you should not use diazepam 10 mg UK.
- acute alcohol intoxication
- closed-angle glaucoma (an eye disorder)
- drug dependence or abuse
- renal/liver diseases
- respiratory depression
- prolonged hypotension (decreased blood pressure)
- myasthenia gravis (a medical condition that includes weakness of muscles)
- renal/liver disease
- paradoxical reactions (an opposite effect or reaction of the intended one, in benzodiazepines, increased talkativeness, emotional release, excitement, and excessive movement)
Diazepam 10 mg UK adverse effects differentiate into adverse effects that require immediate medical attention and those that don’t.
Adverse effects require immediate medical attention:
- Problems with muscle control and coordination
Incidence not known
- Abdominal and stomach pain
- Black and tarry stool, or dark urine
- Blurred vision
- Speech problems
- Decrease in urine frequency or volume
- difficulty in urination
- Unusual behavior
Adverse effects don’t require immediate medical attention:
Incidence not known
- Decreased or increased sexual desire
- Swallowing difficulties
- Double vision
- Dry mouth
- Vertigo (feeling of constant movement of the surroundings)
- Impotence (inability to have or to keep an erection in the males)
Black box warning:
Using diazepam 10 mg UK with opioid medications may be extremely dangerous, causing profound sedation, respiratory depression, coma, and even death.
Diazepam 10 mg UK is a very effective medication that is used in the treatment and management of many disorders.
If you think you suffer from any of the above conditions, discuss with your health care provider if diazepam is suitable for you.